Symptoms of Paget’s disease
September 29, 2008
Paget’s disease is commonly known as ‘bone remodelling disorder’. Inactive tissue-like bones are the major characteristic symptom of this disease. Our bones are undergoing a constant process of replacement. When new bones are formed, the older ones get absorbed. This is the process of bone remodelling, which usually occurs with out any obstruction. Paget’s disease is caused when certain irregularities creeps into this process. New bones are formed where it is not actually needed. Likewise, the old bones get removed when the body actually is in need of them. Paget’s disease thus disrupts the normal skeletal design of the human body.
Though the true reason behind the cause of this disorder is not yet known, a virus termed paramyxovirus nucleocapsid is found to be present in the bone cells of people with Paget’s disease. Another aspect of the Paget’s disease is that it is found to be common in certain geographical locations such as England, Western Europe, and the United States. Paget’s disease rarely get reported in India, China and Scandinavia.
The most common symptom of Paget’s disease is severe joint pain. Swelling and tenderness of bones are also seen in some cases. In many cases, the disorder remains unnoticed until a fracture occurs in the weakened bone. Femur (thigh bone), pelvis, skull, spine and tibia (shin bone) are the bones that are easily affected by Paget’s disease. Increased level of alkaline phosphates, which is a by-product of bone formation, is yet another indicator of this disorder.
Paget’s disease gets diagnosed either through physical examination by specialists or through x-rays. Physical examination reveals skeletal deformities and bone deformations where as only an x-ray can provide a clear picture of increased or decreased bone deposition. X-rays also bring out bone turnover, if any. Though Paget’s disease causes bone deformations, it does not affect the level of calcium in the body.
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